Guo Xu-Feng, Wang Jun, Lei Xiao-Fei, Zeng Yan-Ping, Dong Wei-Guo
Department of Gastroenterology, Renmin Hospital of Wuhan University, China.
Intern Med. 2015;54(3):251-9. doi: 10.2169/internalmedicine.54.3256.
Published data regarding the association between xeroderma pigmentosum group D XPD Lys751Gln polymorphisms and esophageal cancer (EC) cancer remain controversial. The present meta-analysis aimed to obtain a more precise estimation of the relationship between XPD Lys751Gln polymorphisms and the risk of EC.
All eligible case-control studies of Lys751Gln polymorphisms and susceptibility to EC were selected from PubMed, Web of Science and CNKI up to October 2013. The data were extracted, and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.
A total of 21 case-control studies from 19 reports were assessed in this meta-analysis, including 6,581 cases and 8,251 controls. There was a significant association between the XPD Lys751Gln polymorphism and the risk of esophageal cancer in the overall population (Dominant model: OR=1.30, 95%CI: 1.07-1.57, p<0.05; Lys/Gln vs. Gln/Gln: OR=1.20, 95%CI: 1.05-137, p<0.05; Gln/Gln vs. Lys/Lys: OR=1.76, 95%CI: 1.08-2.85, p=0.02; Recessive model: OR=1.48, 95%CI: 1.06-2.07, p=0.02). Similar results were found when stratified according to the cancer type, ethnicity and control source. However, no associations were found among smokers or drinkers.
The results of this meta-analysis suggest that XPD Lys751Gln polymorphisms contribute to susceptibility to EC.
关于着色性干皮病D组（XPD）Lys751Gln多态性与食管癌（EC）之间关联的已发表数据仍存在争议。本荟萃分析旨在更精确地评估XPD Lys751Gln多态性与EC风险之间的关系。
从PubMed、Web of Science和中国知网中选取截至2013年10月所有符合条件的关于Lys751Gln多态性与EC易感性的病例对照研究。提取数据，并计算合并比值比（OR）及95%置信区间（CI）。
本荟萃分析共评估了19篇报告中的21项病例对照研究，包括6581例病例和8251例对照。在总体人群中，XPD Lys751Gln多态性与食管癌风险之间存在显著关联（显性模型：OR = 1.30，95%CI：1.07 - 1.57，p < 0.05；Lys/Gln vs. Gln/Gln：OR = 1.20，95%CI：1.05 - 1.37，p < 0.05；Gln/Gln vs. Lys/Lys：OR = 1.76，95%CI：1.08 - 2.85，p = 0.02；隐性模型：OR = 1.48，95%CI：1.06 - 2.07，p = 0.02）。按癌症类型、种族和对照来源分层时发现了类似结果。然而，在吸烟者或饮酒者中未发现关联。
本荟萃分析结果表明，XPD Lys751Gln多态性与EC易感性有关。
