Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, United States.
World J Gastroenterol. 2011 May 28;17(20):2520-35. doi: 10.3748/wjg.v17.i20.2520.
Liver diseases are an increasingly common cause of morbidity and mortality; new approaches for investigation of mechanisms of liver diseases and identification of therapeutic targets are emergent. Lipid rafts (LRs) are specialized domains of cellular membranes that are enriched in saturated lipids; they are small, mobile, and are key components of cellular architecture, protein partition to cellular membranes, and signaling events. LRs have been identified in the membranes of all liver cells, parenchymal and non-parenchymal; more importantly, LRs are active participants in multiple physiological and pathological conditions in individual types of liver cells. This article aims to review experimental-based evidence with regard to LRs in the liver, from the perspective of the liver as a whole organ composed of a multitude of cell types. We have gathered up-to-date information related to the role of LRs in individual types of liver cells, in liver health and diseases, and identified the possibilities of LR-dependent therapeutic targets in liver diseases.
肝脏疾病是发病率和死亡率日益增加的主要原因；探索肝脏疾病机制和确定治疗靶点的新方法正在出现。脂筏（LRs）是富含饱和脂质的细胞膜特化区域；它们体积小、流动性强，是细胞结构、蛋白质向细胞膜分配和信号事件的关键组成部分。LRs 已在所有肝细胞膜（实质细胞和非实质细胞）中被识别；更重要的是，LRs 是个体类型的肝细胞膜中多种生理和病理状况的积极参与者。本文旨在从由多种细胞类型组成的整体器官的角度，综述关于肝脏中 LRs 的基于实验的证据。我们收集了与 LRs 在各种肝细胞膜中的作用相关的最新信息，探讨了 LRs 在肝脏健康和疾病中的作用，并确定了 LRs 依赖性治疗靶点在肝脏疾病中的可能性。
