用快速纤维状阴离子交换树脂从[18O]水中提取[18F]氟化物。

Extraction of [18F]fluoride from [18O]water by a fast fibrous anion exchange resin.

作者信息

Jewett D M, Toorongian S A, Bachelor M A, Kilbourn M R

机构信息

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109-0552.

出版信息

Int J Rad Appl Instrum A. 1990;41(6):583-6. doi: 10.1016/0883-2889(90)90044-h.

DOI:10.1016/0883-2889(90)90044-h

PMID:2163375

Abstract

[18F]Fluoride for nucleophilic radiofluorination was recovered from target water by trapping on a fibrous anion exchange resin in the hydroxide form and subsequent displacement into wet methanolic K2CO3. Extraction into methanol facilitated rapid evaporation and resolubilization of the [18F]fluoride as an ion pair. The resin was first dried in situ and rehydrated with [18O]H2O to avoid isotopic dilution of the target water.

摘要

用于亲核放射性氟化的[18F]氟化物通过捕获在氢氧化物形式的纤维状阴离子交换树脂上，然后置换到湿的甲醇碳酸钾中，从靶水中回收。萃取到甲醇中有助于[18F]氟化物作为离子对快速蒸发和再溶解。树脂首先在原位干燥，并用[18O]H2O再水化，以避免靶水的同位素稀释。