Jewett D M, Toorongian S A, Mulholland G K, Watkins G L, Kilbourn M R
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109-0552.
Int J Rad Appl Instrum A. 1988;39(11):1109-11. doi: 10.1016/0883-2889(88)90001-9.
In multiphase extraction [18F]fluoride ion for radiolabeling is recovered from target water by passage through a small column of microporous polymer impregnated with a lipophilic cryptand or quaternary ammonium salt. The 18O enriched water can be recovered for reuse. The [18F]fluoride ion-pair is eluted from the column by a small volume of acetonitrile or other organic solvent. Evaporation of the acetonitrile removes traces of water to yield a reactive ion pair for nucleophilic radiofluorination reactions. A wide range of ion-pairs based on K+ or NH+4 cryptands or quaternary ammonium salts can be employed. The method was applied to the synthesis of [18F]FDG.
在多相萃取中，用于放射性标记的[18F]氟离子通过一小柱浸渍有亲脂性穴状配体或季铵盐的微孔聚合物从目标水中回收。富含18O的水可回收再利用。[18F]氟离子对通过少量乙腈或其他有机溶剂从柱中洗脱。乙腈的蒸发去除了痕量的水，得到用于亲核放射性氟化反应的活性离子对。可以使用基于K+或NH+4穴状配体或季铵盐的多种离子对。该方法应用于[18F]FDG的合成。
