Center for Autoimmune Disease, Rheumatology Unit, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Clin Rev Allergy Immunol. 2012 Apr;42(2):238-46. doi: 10.1007/s12016-011-8275-x.
Mixed cryoglobulinemia (MC) syndrome is an immune complex-mediated vasculitis characterized by the clinical triad of purpura, weakness, and arthralgias, the morbidity of which is mainly related to kidney and peripheral nervous system dysfunction as well as to the development of a secondary lymphoma (Ferri et al. Autoimmun Rev 7:114-120, 2007, Lidar et al. Ann N Y Acad Sci 1173:649-657, 2009, Trejo et al. Semin Arthritis Rheum 33:19-28, 2003). MC is associated with infectious and systemic disorders, principally autoimmune and lymphoproliferative diseases. Since the 1990s, a striking association (>90%) between MC and hepatitis C virus (HCV) infection has been established (Ferri and Bombardieri 2004; Pascual et al. J Infect Dis 162:569-570, 1990). However, information regarding the etiopathogenesis of HCV-negative MC is scant (Mascia et al. Dig Liver Dis 39:61-64, 2007). We hereby present our findings, as well as previously published data, regarding the presence of antibodies against infectious agents and autoantibodies in patients with MC in an attempt to establish novel associations which may shed light on the etiopathogenesis of this disease.
混合性冷球蛋白血症 (MC) 综合征是一种免疫复合物介导的血管炎，其特征是紫癜、乏力和关节痛三联征，发病率主要与肾脏和周围神经系统功能障碍以及继发性淋巴瘤的发展有关 (Ferri 等人，Autoimmun Rev 7:114-120, 2007; Lidar 等人，Ann N Y Acad Sci 1173:649-657, 2009; Trejo 等人， Semin Arthritis Rheum 33:19-28, 2003)。MC 与感染和全身性疾病有关，主要是自身免疫和淋巴增生性疾病。自 20 世纪 90 年代以来，MC 与丙型肝炎病毒 (HCV) 感染之间存在显著关联 (>90%) (Ferri 和 Bombardieri 2004; Pascual 等人，J Infect Dis 162:569-570, 1990)。然而，关于 HCV 阴性 MC 的病因学信息很少 (Mascia 等人，Dig Liver Dis 39:61-64, 2007)。我们在此介绍了我们的研究结果以及之前发表的数据，这些数据涉及 MC 患者体内针对感染性病原体和自身抗体的存在，试图确定新的关联，这可能有助于阐明该疾病的病因学。
