State Key laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 PR China.
Chemistry. 2011 Jul 11;17(29):8189-94. doi: 10.1002/chem.201100194. Epub 2011 Jun 1.
A robust and photoresponsive DNA network has been designed and constructed from branched DNA and molecular glue. The molecular glue is photoswitchable and can specifically bind to G-G mismatched double-stranded DNA. The assembly process can be reversibly controlled by manipulating the wavelength of light. The approach is flexible, allowing tuning of the size, morphology as well as the cavity of the network by variation of the molar ratio and the isotropic/anisotropic character of the branched building blocks. The assembled architectures are versatile and heat tolerant. These properties should allow the use of the network in further applications.
已设计并构建了一种由分支 DNA 和分子胶组成的坚固且对光响应的 DNA 网络。该分子胶是光致开关的，并且可以特异性地与 G-G 错配的双链 DNA 结合。通过操纵光的波长，可以可逆地控制组装过程。该方法具有灵活性，通过改变分支构建块的摩尔比和各向同性/各向异性特征，可以调整网络的大小、形态以及腔室。组装的结构具有多功能性和耐热性。这些特性应该允许在进一步的应用中使用该网络。
