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[萨哈(雅库特)人群中六个微卫星DNA位点的等位基因多态性]

[Allelic polymorphism of six microsatellite DNA loci in populations of Sakha (Yakutia)].

作者信息

Zhirkova V V, Fedorova S A, Akhmetova V L, Zhivotovskiĭ L A, Khusnutdinov E K

出版信息

Mol Biol (Mosk). 2011 Mar-Apr;45(2):249-57.

Abstract

The distribution of allele frequencies of six STR-loci (D3S1358, D16S539, THOI, D8S1179, LPL, HUMvWFII), used in forensic practice, was analyzed in populations of Sakha (Yakutia) (three ethnogeographical groups of Sakha (Yakuts), Evenks, Yukagirs, Dolgans, Russians). Significant differences were revealed between the Russians and all other populations by five markers. Values of total discriminative potential (PD) of studied system for each population were estimated. The level of interpopulation genetic differences (F(ST)) was 0.005. On the basis of allelic polymorphism of STR-loci we estimated phylogenetic relationships between populations under study and populations of different regions--East Europe, South Siberia, Chukotka and Kamchatka.

摘要

分析了法医实践中使用的六个STR基因座(D3S1358、D16S539、THOI、D8S1179、LPL、HUMvWFII)的等位基因频率在萨哈(雅库特)人群(萨哈(雅库特)人、埃文克人、尤卡吉尔人、多尔干人、俄罗斯人的三个民族地理群体)中的分布情况。通过五个标记发现俄罗斯人与所有其他群体之间存在显著差异。估计了所研究系统对每个群体的总鉴别潜力(PD)值。群体间遗传差异水平(F(ST))为0.005。基于STR基因座的等位基因多态性,我们估计了所研究群体与不同地区群体(东欧、南西伯利亚、楚科奇和堪察加)之间的系统发育关系。

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