早产儿视网膜病变中的胰岛素样生长因子-I和内脂素水平
IGF-I and visfatin levels in retinopathy of prematurity.
作者信息
Cekmez Ferhat, Canpolat Fuat Emre, Çetinkaya Merih, Pirgon Ozgur, Aydinoz Secil, Ceylan O Melih, Ipcioglu O Metin, Sarici Serdar Umit
机构信息
Division of Neonatology, Department of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey.
出版信息
J Pediatr Ophthalmol Strabismus. 2012 Mar-Apr;49(2):120-4. doi: 10.3928/01913913-20110531-01. Epub 2011 Jun 7.
PURPOSE
The authors hypothesized that circulating visfatin concentrations in preterm infants might be linked with retinopathy of prematurity (ROP)-like insulin-like growth factor I (IGF-I) levels.
METHODS
The study group comprised 88 children born with a gestational age younger than 32 weeks between 2007 and 2009 who were screened and/or treated for ROP. The authors collected fetal cord blood (sample 1) and a blood sample at 4 to 6 weeks postnatal age (sample 2) for laboratory investigations.
RESULTS
The non-ROP group had higher visfatin-1, visfatin-2, insulin-1, insulin-2, (IGF-I)-1, and (IGF-I)-2 levels than the ROP group (P < .001 for all levels). Change in visfatin was positively correlated with change in IGF-I and change in insulin (P < .001 and P < .001, respectively). Change in IGF-I was positively correlated with change in insulin (P < .001).
CONCLUSION
Similar to IGF-I levels, determination of visfatin levels can be a predictive marker of ROP, but more studies are needed.
目的
作者推测早产儿循环内脂素浓度可能与早产儿视网膜病变（ROP）样胰岛素样生长因子I（IGF-I）水平有关。
方法
研究组包括2007年至2009年间出生时胎龄小于32周且接受ROP筛查和/或治疗的88名儿童。作者采集了胎儿脐带血（样本1）和出生后4至6周的血样（样本2）进行实验室检查。
结果
非ROP组的内脂素-1、内脂素-2、胰岛素-1、胰岛素-2、（IGF-I）-1和（IGF-I）-2水平高于ROP组（所有水平P <.001）。内脂素变化与IGF-I变化和胰岛素变化呈正相关（分别为P <.001和P <.001）。IGF-I变化与胰岛素变化呈正相关（P <.001）。
结论
与IGF-I水平类似，内脂素水平的测定可能是ROP的预测标志物，但仍需更多研究。
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