Briana Despina D, Boutsikou Maria, Gourgiotis Dimitrios, Kontara Louiza, Baka Stavroula, Iacovidou Nicoletta, Hassiakos Dimitrios, Malamitsi-Puchner Ariadne
2nd Department of Obstetrics and Gynecology, Neonatal Division, Athens University Medical School, Athens, Greece.
J Perinat Med. 2007;35(4):326-9. doi: 10.1515/JPM.2007.071.
IGF-I and insulin are the main regulators of intrauterine and postnatal growth. Adipose tissue secreted cytokines are implicated in intrauterine growth. The relevant function of the adipocytokine visfatin is unknown.
Serum visfatin, IGF-I and insulin levels were measured by enzyme immunoassays in 40 singleton full-term fetuses and neonates on postnatal days 1(N1) and 4 (N4).
No significant correlations exist between visfatin and IGF-I or insulin. N1 and N4 visfatin positively correlated with customized (adjusted) birth weight centiles (r=0.511, P=0.021, and r=0.597, P=0.005, respectively). Fetal and N1 IGF-I positively correlated with customized centiles (r=0.608, P<0.001 and r=0.485, P=0.006, respectively). Fetal insulin positively correlated with customized centiles (r=0.654, P=0.021).
Potential implication of visfatin in fetal growth is probably not mediated by IGF-I or insulin. Although a more active role cannot be excluded, visfatin may simply represent a marker of fat accumulation.
胰岛素样生长因子-I（IGF-I）和胰岛素是宫内及出生后生长的主要调节因子。脂肪组织分泌的细胞因子与宫内生长有关。内脏脂肪素这种脂肪细胞因子的相关功能尚不清楚。
采用酶免疫分析法测定了40例单胎足月胎儿及出生后第1天（N1）和第4天（N4）的新生儿的血清内脏脂肪素、IGF-I和胰岛素水平。
内脏脂肪素与IGF-I或胰岛素之间无显著相关性。N1和N4时的内脏脂肪素与定制（校正）出生体重百分位数呈正相关（分别为r = 0.511，P = 0.021和r = 0.597，P = 0.005）。胎儿及N1时的IGF-I与定制百分位数呈正相关（分别为r = 0.608，P < 0.001和r = 0.485，P = 0.006）。胎儿胰岛素与定制百分位数呈正相关（r = 0.654，P = 0.021）。
内脏脂肪素对胎儿生长的潜在影响可能不是由IGF-I或胰岛素介导的。虽然不能排除其有更积极的作用，但内脏脂肪素可能只是脂肪堆积的一个标志物。
