Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, Av Diagonal 647, E-08028 Barcelona, Spain.
J Theor Biol. 2011 Aug 21;283(1):28-34. doi: 10.1016/j.jtbi.2011.05.025. Epub 2011 May 25.
There are general features of chromosome dynamics, such as homologue recognition in early meiosis, which are expected to involve related sequence motifs in non-coding DNA, with a similar distribution in different species. A search for such motifs is presented here. It has been carried out with the CONREPP programme. It has been found that short alternating AT sequences (10-20 bases) have a similar distribution in most eukaryotic organisms, with some exceptions related to unique meiotic features. All other microsatellite and repeat sequences vary significantly in different organisms. It is concluded that the unique structural features and uniform distribution of alternating AT sequences indicate that they may facilitate homologous chromosome pairing in the early preleptotene stage of meiosis. They may also play a role in the compaction of DNA in mitotic chromosomes.
染色体动力学具有一些普遍特征，例如早期减数分裂中同源物的识别，这预计涉及非编码 DNA 中的相关序列基序，并且在不同物种中具有相似的分布。本文提出了一种寻找此类基序的方法。该方法使用 CONREPP 程序进行。结果发现，大多数真核生物中都有类似分布的短交替 AT 序列（10-20 个碱基），但也有一些例外与独特的减数分裂特征有关。所有其他微卫星和重复序列在不同生物体中差异很大。结论是，交替 AT 序列的独特结构特征和均匀分布表明，它们可能有助于减数分裂早期预细线期同源染色体的配对。它们也可能在有丝分裂染色体的 DNA 压缩中发挥作用。
