Zebrafish Neurogenetics Group, Laboratory of Neurobiology and Development (NED), Institute of Neurobiology Albert Fessard, Gif-sur-Yvette, France.
J Chem Neuroanat. 2011 Jul;41(4):294-308. doi: 10.1016/j.jchemneu.2011.05.009. Epub 2011 May 23.
Neurons using serotonin (5-HT) as neurotransmitter and/or modulator have been identified in the central nervous system in representatives from all vertebrate clades, including jawless, cartilaginous and ray-finned fishes. The aim of this review is to summarize our current knowledge about the anatomical organization of the central serotonergic system in fishes. Furthermore, selected key functions of 5-HT will be described. The main focus will be the adult brain of teleosts, in particular zebrafish, which is increasingly used as a model organism. It is used to answer not only genetic and developmental biology questions, but also issues concerning physiology, behavior and the underlying neuronal networks. The many evolutionary conserved features of zebrafish combined with the ever increasing number of genetic tools and its practical advantages promise great possibilities to increase our understanding of the serotonergic system. Further, comparative studies including several vertebrate species will provide us with interesting insights into the evolution of this important neurotransmitter system.
中枢神经系统中使用血清素（5-HT）作为神经递质和/或调质的神经元已在所有脊椎动物类群的代表中被鉴定出来，包括无颌类、软骨鱼类和硬骨鱼类。本综述旨在总结我们目前对鱼类中枢 5-HT 能系统的解剖组织的认识。此外，还将描述 5-HT 的一些关键功能。主要重点将是硬骨鱼的成年大脑，特别是斑马鱼，它越来越多地被用作模式生物。它不仅用于回答遗传和发育生物学问题，还用于解决生理学、行为和潜在的神经元网络问题。斑马鱼具有许多进化保守的特征，结合越来越多的遗传工具及其实际优势，有望增加我们对 5-HT 能系统的理解。此外，包括几个脊椎动物物种的比较研究将为我们提供有关这个重要的神经递质系统进化的有趣见解。
