Department of Rehabilitation Sciences and Physiotherapy, Ghent University, Artevelde University College, Ghent, Belgium.
Arch Phys Med Rehabil. 2011 Jul;92(7):1106-12. doi: 10.1016/j.apmr.2011.01.016. Epub 2011 Jun 2.
To describe medication use, surgery, and physiotherapy, and to examine the effect of these treatment modalities on functional impairment and amount of complaints among patients with the hypermobility type of Ehlers-Danlos syndrome (EDS-HT).
Cross-sectional study.
Physical and rehabilitation medicine department and center for medical genetics.
Patients with EDS-HT (N=79; 8 men, 71 women) were recruited for this study.
Not applicable.
Patients filled out questionnaires regarding type of complaints, medication use, surgery, physiotherapy, and outcome of treatment. Functional impairment in daily life was measured by the Sickness Impact Profile. Pain severity was assessed with visual analog scales.
Patients reported a large number of complaints, a considerable presence of severe pain, and a clinically significant impact of disease on daily functioning. Most patients (92.4%) used medications, among which analgesics were the most prevalent. Fifty-six patients (70.9%) underwent surgery, including mainly interventions of the extremities and abdomen. Forty-one patients (51.9%) are currently enrolled in a physical therapy program, mainly comprising neuromuscular exercises, massage, and electrotherapy. Patients with a high consumption of analgesics, who visited the physiotherapist, or who underwent surgery had a higher dysfunction in daily life. Only 33.9% of the patients who underwent surgery and 63.4% of patients in physical therapy reported a positive outcome.
Patients with EDS-HT have numerous complaints and an impaired functional status that strongly determine their high rate of treatment consumption. The outcome of surgical and physiotherapy treatment is disappointing in a large percentage, which illustrates a strong need for evidence-based therapy.
描述药物治疗、手术和物理疗法，并探讨这些治疗方式对 Ehlers-Danlos 综合征（EDS）过度活动型患者功能障碍和抱怨程度的影响。
横断面研究。
物理医学和康复科及医学遗传学中心。
共招募了 79 例 EDS-HT 患者（8 名男性，71 名女性）参与本研究。
无。
患者填写了有关抱怨类型、药物使用、手术、物理治疗和治疗效果的问卷。日常生活中的功能障碍通过 Sickness Impact Profile 进行评估。疼痛严重程度采用视觉模拟评分量表进行评估。
患者报告了大量的抱怨，严重疼痛的发生率高，疾病对日常生活的影响具有临床意义。大多数患者（92.4%）使用药物，其中镇痛药最为常见。56 例患者（70.9%）接受了手术，主要包括四肢和腹部的干预。41 例患者（51.9%）目前正在接受物理治疗计划，主要包括神经肌肉锻炼、按摩和电疗。使用大量镇痛药、接受物理治疗或接受手术的患者日常生活功能障碍更为严重。接受手术的患者中仅有 33.9%和接受物理治疗的患者中 63.4%报告治疗效果良好。
EDS-HT 患者抱怨众多，功能状态受损，这强烈表明他们需要大量的治疗。手术和物理治疗的效果令人失望，很大比例的患者报告治疗效果不佳，这表明迫切需要循证治疗。
