乳过氧化物酶化合物I和II对苄青霉素G进行单电子氧化的证据。
Evidence for one-electron oxidation of benzylpenicillin G by lactoperoxidase compounds I and II.
作者信息
Metodiewa D, Dunford H B
机构信息
Department of Chemistry, University of Alberta, Edmonton, Canada.
出版信息
Biochem Biophys Res Commun. 1990 Jun 29;169(3):1211-6. doi: 10.1016/0006-291x(90)92025-u.
The ability of the widely used antibiotic benzylpenicillin G to undergo a peroxidatic oxidation to produce free radical species has been investigated using conventional spectrophotometry, rapid scan spectrophotometry and an ESR spin trapping technique. Lactoperoxidase was used as a model for a drug oxidizing system. The results of the investigation indicate a normal peroxidatic pathway of benzylpenicillin degradation which leads to superoxide radical generation.
已使用传统分光光度法、快速扫描分光光度法和电子自旋共振自旋捕获技术研究了广泛使用的抗生素苄青霉素G进行过氧化氧化以产生自由基的能力。乳过氧化物酶被用作药物氧化系统的模型。研究结果表明苄青霉素降解存在正常的过氧化途径，该途径会导致超氧自由基的产生。
Zotero 插件