硫醇类药物和生物化学物质被乳过氧化物酶/过氧化氢系统氧化。
Oxidation of thiol drugs and biochemicals by the lactoperoxidase/hydrogen peroxide system.
作者信息
Mottley C, Toy K, Mason R P
出版信息
Mol Pharmacol. 1987 Apr;31(4):417-21.
The thiol moiety is prone to oxidative free radical formation, which may be important in mediating the toxicity of some thiol-containing compounds. The oxidation of the compounds cysteine, cysteamine, N-acetylcysteine, glutathione, penicillamine, and captopril were studied using ESR and oxygen uptake techniques. Lactoperoxidase, with hydrogen peroxide to provide oxidizing equivalents, was used to initiate the oxidation. The reaction appears to be strongly peroxide dependent, with either exogenous H2O2 or thiol-derived peroxide driving the reaction.
硫醇部分易于形成氧化自由基，这在介导某些含硫醇化合物的毒性方面可能很重要。使用电子自旋共振（ESR）和氧摄取技术研究了半胱氨酸、半胱胺、N-乙酰半胱氨酸、谷胱甘肽、青霉胺和卡托普利等化合物的氧化。用乳过氧化物酶和过氧化氢提供氧化当量来引发氧化反应。该反应似乎强烈依赖过氧化物，外源性过氧化氢或硫醇衍生的过氧化物均可驱动反应。
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