Centre Hospitalier Régional Universitaire de Montpellier, Hôpital Arnaud de Villeneuve, Service de Pédiatrie générale, Maladies Infectieuses, Immunologie Clinique, 371, Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France.
J Cyst Fibros. 2011 Sep;10(5):377-82. doi: 10.1016/j.jcf.2011.05.001. Epub 2011 Jun 1.
We report the isolation of Staphylococcus aureus with decreased susceptibility to glycopeptides in five CF patients and review the clinical and microbiological features of these cases. Three patients presented with pulmonary exacerbation that may be attributed to these strains and two of them were successfully treated using linezolid therapy. Glycopeptide-intermediate S. aureus (GISA) strains isolated in two patients were susceptible to methicillin, while the three other patients harbored methicillin-resistant GISA. Rarely reported in CF, GISA may remain underestimated due to the difficulty of detection, and both clinicians and microbiologists should be aware of the GISA emergence in CF patients' population.
我们报告了在五例 CF 患者中分离到对糖肽类药物敏感性降低的金黄色葡萄球菌，并回顾了这些病例的临床和微生物学特征。三名患者出现了可能归因于这些菌株的肺部恶化，其中两名患者成功地使用利奈唑胺治疗。从两名患者中分离出的糖肽中介金黄色葡萄球菌 (GISA) 菌株对甲氧西林敏感，而其他三名患者则携带耐甲氧西林的 GISA。GISA 在 CF 中很少见，由于检测困难，可能被低估，临床医生和微生物学家都应该意识到 GISA 在 CF 患者群体中的出现。
