Waikakul S, Chumniprasas K, Setasubun S, Vajaradul Y
Faculty of Medicine, Mahidol University, Siriraj Hospital, Bangkok, Thailand.
Bull Hosp Jt Dis Orthop Inst. 1990 Spring;50(1):27-34.
Sixty five patients (51 males and 14 females) underwent a control trial of freeze-dried amniotic membrane applied in the form of split-thickness skin grafts over an area from which skin had been surgically removed. The average size of the grafts was 15 x 20 cm. The patients were randomly divided into two groups. In the first group (36 patients), the membrane was applied at the upper half of the wound; in the second group (29 patients), the membrane was applied at the lower half of the wound. The remaining areas of the wounds were covered by antibiotic-impregnated fine-mesh greased gauze. Pain, infection, and the progress of healing were monitored. Covering the wound with the amniotic membrane had good results in terms of pain reduction, but the promotion of healing and the prevention of infection were not demonstrated. Hyperemia and hypertrophic scar responses to the membrane in some cases were considered as disadvantages.
65名患者（51名男性和14名女性）接受了一项对照试验，将冻干羊膜以中厚皮片的形式应用于手术去除皮肤的区域。移植皮片的平均尺寸为15×20厘米。患者被随机分为两组。第一组（36名患者），将羊膜应用于伤口的上半部分；第二组（29名患者），将羊膜应用于伤口的下半部分。伤口的其余区域用浸有抗生素的细网凡士林纱布覆盖。监测疼痛、感染和愈合进程。用羊膜覆盖伤口在减轻疼痛方面取得了良好效果，但在促进愈合和预防感染方面未得到证实。在某些情况下，羊膜引起的充血和肥厚性瘢痕反应被视为缺点。
