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Multimodal single-cell analysis provides novel insights on ankylosing spondylitis in females.

作者信息

Chen Hsin-Hua, Wang Jing-Rong, Sung Hsiao-Ni, Chao Wen-Cheng, Liu Kuan-Ting, Lin Fang-Ping, Ko Tai-Ming

机构信息

Division of General Medicine, Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

出版信息

Clin Transl Med. 2022 Oct;12(10):e1066. doi: 10.1002/ctm2.1066.

DOI:10.1002/ctm2.1066
PMID:36207989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9547115/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe7/9547115/3a6a1699e647/CTM2-12-e1066-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe7/9547115/eacff14d61b6/CTM2-12-e1066-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe7/9547115/f57d7f97f791/CTM2-12-e1066-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe7/9547115/a5db17acbfc5/CTM2-12-e1066-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe7/9547115/3a6a1699e647/CTM2-12-e1066-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe7/9547115/eacff14d61b6/CTM2-12-e1066-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe7/9547115/f57d7f97f791/CTM2-12-e1066-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe7/9547115/a5db17acbfc5/CTM2-12-e1066-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe7/9547115/3a6a1699e647/CTM2-12-e1066-g004.jpg

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1
Multimodal single-cell analysis provides novel insights on ankylosing spondylitis in females.多模态单细胞分析为女性强直性脊柱炎提供了新见解。
Clin Transl Med. 2022 Oct;12(10):e1066. doi: 10.1002/ctm2.1066.
2
Measures of symptoms and disease status in ankylosing spondylitis: Ankylosing Spondylitis Disease Activity Score (ASDAS), Ankylosing Spondylitis Quality of Life Scale (ASQoL), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Global Score (BAS-G), Bath Ankylosing Spondylitis Metrology Index (BASMI), Dougados Functional Index (DFI), and Health Assessment Questionnaire for the Spondylarthropathies (HAQ-S).强直性脊柱炎的症状和疾病状态测量指标：强直性脊柱炎疾病活动评分（ASDAS）、强直性脊柱炎生活质量量表（ASQoL）、巴氏强直性脊柱炎疾病活动指数（BASDAI）、巴氏强直性脊柱炎功能指数（BASFI）、巴氏强直性脊柱炎整体评分（BAS-G）、巴氏强直性脊柱炎计量指数（BASMI）、杜加多斯功能指数（DFI）以及脊柱关节病健康评估问卷（HAQ-S）。
Arthritis Care Res (Hoboken). 2011 Nov;63 Suppl 11:S47-58. doi: 10.1002/acr.20575.
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Is disease severity in ankylosing spondylitis genetically determined?强直性脊柱炎的疾病严重程度是由基因决定的吗？
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本文引用的文献

1
Ankylosing spondylitis: an autoimmune or autoinflammatory disease?强直性脊柱炎：一种自身免疫性疾病还是自身炎症性疾病？
Nat Rev Rheumatol. 2021 Jul;17(7):387-404. doi: 10.1038/s41584-021-00625-y. Epub 2021 Jun 10.
2
Inference and analysis of cell-cell communication using CellChat.使用 CellChat 进行细胞间通讯的推断和分析。
Nat Commun. 2021 Feb 17;12(1):1088. doi: 10.1038/s41467-021-21246-9.
3
Gender Differences in Axial Spondyloarthritis: Women Are Not So Lucky.性别差异与中轴型脊柱关节炎：女性并非如此“幸运”。
Curr Rheumatol Rep. 2018 May 12;20(6):35. doi: 10.1007/s11926-018-0744-2.
4
Simultaneous epitope and transcriptome measurement in single cells.单细胞中表位和转录组的同步测量。
Nat Methods. 2017 Sep;14(9):865-868. doi: 10.1038/nmeth.4380. Epub 2017 Jul 31.
5
Pathogenesis of ankylosing spondylitis - recent advances and future directions.强直性脊柱炎的发病机制——最新进展与未来方向。
Nat Rev Rheumatol. 2017 Jun;13(6):359-367. doi: 10.1038/nrrheum.2017.56. Epub 2017 Apr 27.
6
NF-κB: roles and regulation in different CD4(+) T-cell subsets.NF-κB：不同 CD4(+) T 细胞亚群中的作用和调控。
Immunol Rev. 2013 Mar;252(1):41-51. doi: 10.1111/imr.12033.
7
Female patients with ankylosing spondylitis: analysis of the impact of gender across treatment studies.女性强直性脊柱炎患者：治疗研究中跨性别影响的分析。
Ann Rheum Dis. 2013 Jul;72(7):1221-4. doi: 10.1136/annrheumdis-2012-202431. Epub 2012 Dec 22.
8
TL1A/TNFSF15 directly induces proinflammatory cytokines, including TNFα, from CD3+CD161+ T cells to exacerbate gut inflammation.TL1A/TNFSF15 可直接诱导 CD3+CD161+T 细胞产生促炎细胞因子，如 TNFα，从而加重肠道炎症。
Mucosal Immunol. 2013 Sep;6(5):886-99. doi: 10.1038/mi.2012.124. Epub 2012 Dec 19.
9
GIMAP Proteins in T-Lymphocytes.T淋巴细胞中的GIMAP蛋白
J Signal Transduct. 2010;2010:268589. doi: 10.1155/2010/268589. Epub 2010 Aug 31.
10
Vascular endothelial growth inhibitor (VEGI), an endogenous negative regulator of angiogenesis.血管内皮生长抑制剂（VEGI），一种血管生成的内源性负调控因子。
Semin Ophthalmol. 2006 Jan-Mar;21(1):49-58. doi: 10.1080/08820530500511446.