Huang C, Wu M
Zhonghua Yi Xue Za Zhi. 1990 Mar;70(3):138-9, 12.
Superoxide dismutase (SOD) activity in hepatocellular carcinoma (HCC) tissue was studied. It was observed that activities of total SOD, Cu, Zn-SOD and Mn-SOD in HCC tissue were lower than those in normal liver tissues respectively (P less than 0.001 & 0.01 less than P less than 0.05). SOD activity in poorly differentiated HCC tissue was lower than that in well differentiated HCC tissue. Contents of copper, zinc and manganese in HCC tissues were lower than those in normal liver tissues respectively (P less than 0.001 & P less than 0.01). This study suggests that decreased content of copper, zinc and manganese may be one of the factors that lead to impairment of SOD activity. The characteristic of lower SOD activity in HCC tissue and poorly differentiated HCC tissue may be a negative regulation to limitless proliferation and poor differentiation of liver cancer cells.
对肝细胞癌（HCC）组织中的超氧化物歧化酶（SOD）活性进行了研究。观察到HCC组织中总SOD、铜锌超氧化物歧化酶（Cu, Zn-SOD）和锰超氧化物歧化酶（Mn-SOD）的活性分别低于正常肝组织（P＜0.001和0.01＜P＜0.05）。低分化HCC组织中的SOD活性低于高分化HCC组织。HCC组织中铜、锌和锰的含量分别低于正常肝组织（P＜0.001和P＜0.01）。本研究表明，铜、锌和锰含量降低可能是导致SOD活性受损的因素之一。HCC组织和低分化HCC组织中SOD活性较低的特征可能是对肝癌细胞无限增殖和低分化的一种负调控。
