Shao Y F
Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing.
Zhonghua Zhong Liu Za Zhi. 1990 Jan;12(1):46-8.
Five cases of hereditary site-specific colon cancer (HSSCC or Lynch syndrome I) from two families are reported. The main features of HSSCC are: an autosomal dominant model of heredity, the absence of associated polyposis, the average age being younger, vulnerable site being the right colon (4/5 cases), multiple colon cancers (3/5 cases) and long survival. These 5 cases possessed the above mentioned features. Having no special detection method, the authors suggest that the members of these families be registered and the high risk members regularly checked.
报告了来自两个家族的5例遗传性特定部位结肠癌（HSSCC或林奇综合征I型）。HSSCC的主要特征为：常染色体显性遗传模式、无相关息肉病、平均发病年龄较轻、好发部位为右半结肠（5例中有4例）、多原发性结肠癌（5例中有3例）以及生存期长。这5例均具备上述特征。由于尚无特殊检测方法，作者建议对这些家族成员进行登记，并对高危成员定期检查。
