一种来自獐牙菜的新型细胞毒素 β-咔啉生物碱。
A new cytotoxic β-carboline alkaloid from Galianthe thalictroides.
机构信息
Departamento de Química, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
出版信息
Planta Med. 2011 Nov;77(16):1852-4. doi: 10.1055/s-0030-1271154. Epub 2011 Jun 1.
A cytotoxicity-guided fractionation of the roots of Galianthe thalictroides afforded a new β-carboline alkaloid, 1-(hydroxymethyl)-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H- β-carbolin-1-yl)cyclopentanol, which exhibited strong cytotoxic activity against three human cancer cell lines (MCF-7, 786-0, and UACC62). Its structure was established on the basis of 1D- and 2D-NMR spectroscopic techniques supported by HRMS data.
从山苦荬根的细胞毒性指导部分得到一个新的β-咔啉生物碱，1-（羟甲基）-3-（2-羟基-2-甲基丙基）-2-（5-甲氧基-9H-β-咔啉-1-基）环戊醇，对三种人癌细胞系（MCF-7、786-0 和 UACC62）具有很强的细胞毒性。其结构是基于 1D 和 2D-NMR 光谱技术，并辅以 HRMS 数据确定的。
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