[瑞士恩特勒布赫山犬的遗传性眼部疾病：一项1999年至2009年的回顾性研究]

[Hereditary eye dieseas in the Entlebucher Mountaindog in Switzerland: a retrospective study from 1999 to 2009].

作者信息

Kuster N, Hässig M, Spiess B

机构信息

Departement für Pferde, Abteilung Ophthalmologie der Universität Zürich.

出版信息

Schweiz Arch Tierheilkd. 2011 Jun;153(6):269-75. doi: 10.1024/0036-7281/a000201.

DOI:10.1024/0036-7281/a000201

PMID:21638263

Abstract

The aim of this study was to analyze the prevalence and the incidence of hereditary cataract and progressive retinal atrophy (PRA) in the Entlebucher Mountaindog (EMD) and to evaluate possible changes over time. In addition, the influence of selective breeding programs and DNA-testing for PRA was also investigated. Data of eye certifications for hereditary eye diseases was used. Between 1999 and 2009 a total of 798 ocular examinations were carried out in 285 EMD. 20.4 % had cataracts and 69 % of these were of the posterior polar type. PRA was diagnosed in 6.3 % of the dogs. Cataracts were diagnosed at 5.24 ± 2.71 years (mean ± standard error), while PRA was diagnosed at 4.93 ± 1.32 years of age. The incidence of PRA and cataract showed a decreasing trend (p-value > 0.2) without being significant.

摘要

本研究的目的是分析恩特雷布赫山犬（EMD）遗传性白内障和进行性视网膜萎缩（PRA）的患病率和发病率，并评估随时间可能发生的变化。此外，还研究了选择性育种计划和PRA DNA检测的影响。使用了遗传性眼病的眼部认证数据。1999年至2009年间，对285只EMD进行了总共798次眼部检查。20.4%的犬患有白内障，其中69%为后极性白内障。6.3%的犬被诊断为PRA。白内障诊断年龄为5.24±2.71岁（平均值±标准误差），而PRA诊断年龄为4.93±1.32岁。PRA和白内障的发病率呈下降趋势（p值>0.2），但不显著。