Imperial College London, Chemical Engineering and Chemical Technology, Centre for Process Systems Engineering and Institute for Systems and Synthetic Biology, London, UK.
IET Syst Biol. 2011 May;5(3):208-19. doi: 10.1049/iet-syb.2010.0048.
In this study, the author examines the effects of saturation and enzyme limitation in temporal and spatial signal transduction in a generic feedforward adaptive module. The feedforward module encompasses a range of temporal and spatial signal processing, and this study systematically examines the effect of enzyme limitation/saturating effects in each of the feedforward pathways, and their interplay. It is found that this saturation makes the adaptation inexact, and this effect is more pronounced for higher levels of input signals. Further, it has a very significant role in affecting the temporal dynamics of this module. In examining the role of saturation in the module response to static gradients, the author finds that in certain cases, saturation can completely alter the gradient response. The author examines various aspects of the response systematically using analytical methods and simulations. Overall the author studies a framework and basis for examining and understanding the roles of saturating effects in multiple pathways involved in adaptive responses and sheds light on the relationship and connection between exact and inexact adaptation.
在这项研究中，作者研究了饱和和酶限制对通用前馈自适应模块中时空信号转导的影响。前馈模块包含一系列时空信号处理，本研究系统地检查了酶限制/饱和效应对前馈途径中每个途径的影响，以及它们之间的相互作用。结果发现，这种饱和会使适应变得不准确，而对于更高水平的输入信号，这种效果更为明显。此外，它对模块的时间动态有非常显著的影响。在研究饱和对模块对静态梯度的响应的作用时，作者发现，在某些情况下，饱和可以完全改变梯度响应。作者使用分析方法和模拟系统地研究了响应的各个方面。总的来说，作者研究了一个框架和基础，用于检查和理解在自适应反应中涉及的多个途径中的饱和效应的作用，并揭示了精确和不精确适应之间的关系和联系。
