Krishnan J
Chemical Engineering and Chemical Technology, Centre for Process Systems Engineering and Institute for Systems and Synthetic Biology, Imperial College London, South Kensington Campus, London, UK.
J Theor Biol. 2009 Jul 7;259(1):31-43. doi: 10.1016/j.jtbi.2009.02.015. Epub 2009 Feb 28.
Signal transduction in many cellular processes is accompanied by the feature of adaptation, which allows certain key signalling components to respond to temporal and/or spatial variation of external signals, independent of the absolute value of the signal. We extend and formulate a more general module which accounts for robust temporal adaptation and spatial response. In this setting, we examine various aspects of spatial and temporal signalling, as well as the signalling consequences and restrictions imposed by virtue of adaptation. This module is able to exhibit a variety of behaviour in response to temporal, spatial and spatio-temporal inputs. We carefully examine the roles of various parameters in this module and how they affect signal processing and propagation. Overall, we demonstrate how a simple module can account for a range downstream responses to a variety of input signals, and how elucidating the downstream response of many cellular components in systems with such adaptive signalling can be consequently very non-trivial.
在许多细胞过程中，信号转导伴随着适应性特征，这使得某些关键信号组件能够响应外部信号的时间和/或空间变化，而与信号的绝对值无关。我们扩展并制定了一个更通用的模块，该模块考虑了强大的时间适应性和空间响应。在此背景下，我们研究了空间和时间信号传导的各个方面，以及由于适应性而产生的信号传导后果和限制。该模块能够对时间、空间和时空输入表现出各种行为。我们仔细研究了该模块中各种参数的作用以及它们如何影响信号处理和传播。总体而言，我们展示了一个简单的模块如何能够解释对各种输入信号的一系列下游响应，以及因此阐明具有这种适应性信号传导的系统中许多细胞组件的下游响应可能非常复杂。
