INSERM, U1048, Université Toulouse 3, I2MC, Equipe 9, CHU-Rangueil, Avenue Jean Poulhès BP84225, 31432 Toulouse Cedex 04, France.
Eur J Obstet Gynecol Reprod Biol. 2011 Oct;158(2):141-7. doi: 10.1016/j.ejogrb.2011.04.040. Epub 2011 Jun 2.
Essential thrombocythaemia (ET) is an acquired myeloproliferative neoplasm, characterised by persistent thrombocytosis and a tendency for either thrombosis or haemorrhage. Among myeloproliferative neoplasms, ET is the most prevalent in young women, which constitute a special group due to their childbearing potential. An increased risk of fetal and maternal complications has been demonstrated in patients with ET. The most common pregnancy-related complication is spontaneous abortion during the first trimester. Recurrent abortion, fetal growth restriction, stillbirth and placental abruption are less frequent. Maternal complications are relatively rare and essentially represented by thromboembolic and bleeding events. Here we summarize the literature describing pregnancy and its outcome in patients with ET and discuss some recommendations for the management of pregnancy.
特发性血小板增多症（ET）是一种后天获得性骨髓增殖性肿瘤，其特征为持续性血小板增多，并伴有血栓形成或出血倾向。在骨髓增殖性肿瘤中，ET 在年轻女性中最为常见，由于其生育潜力，这一人群构成了一个特殊的群体。患有 ET 的患者胎儿和母体并发症的风险增加已得到证实。最常见的与妊娠相关的并发症是孕早期自然流产。复发性流产、胎儿生长受限、死产和胎盘早剥则较为少见。母体并发症相对少见，主要表现为血栓栓塞和出血事件。本文总结了描述 ET 患者妊娠及其结局的文献，并讨论了一些妊娠管理的建议。
