Yoshida M, Tezuka T
Department of Dermatology, Kinki University School of Medicine, Osaka, Japan.
J Dermatol. 1990 Apr;17(4):252-4. doi: 10.1111/j.1346-8138.1990.tb01634.x.
A case of a 50-year-old man with recurrent herpes genitalis with two different isolated strains of herpes simplex virus (HSV) type 2 is reported. Morphologically, two types of cytopathic effects (CPE) induced by viruses were observed in the Vero cell cultures, one being a syncytial giant cell formation and the other a rounded cell formation without cell adhesion resembling the CPE induced by ordinary HSV type 2. In this case, it is clinically interesting that the patient complained of persistent pain on the glans and urethra without recurrence of herpetic lesions even after the involution of enanthema. The correlation between the persistent pain and neurovirulence of the two different HSV strains is discussed.
报告了一例50岁男性复发性生殖器疱疹病例，分离出两种不同的2型单纯疱疹病毒（HSV）毒株。在形态学上，在Vero细胞培养物中观察到病毒诱导的两种细胞病变效应（CPE），一种是多核巨细胞形成，另一种是圆形细胞形成且无细胞黏附，类似于普通2型HSV诱导的CPE。在该病例中，临床上有趣的是，即使黏膜疹消退后，患者仍主诉龟头和尿道持续疼痛，疱疹病变未复发。讨论了两种不同HSV毒株的持续疼痛与神经毒力之间的相关性。
