急性克百威中毒后的惊人毛发分析结果。
Surprising hair analysis results following acute carbofuran intoxication.
机构信息
Department of Pharmacology and Toxicology, CHU Dupuytren, 87042 Limoges Cedex, France.
出版信息
Forensic Sci Int. 2011 Oct 10;212(1-3):e10-4. doi: 10.1016/j.forsciint.2011.05.011.
We present two non fatal cases of intoxication with carbofuran (CBF) documented by hair analysis. Carbofuran and 3-hydroxycarbofuran (OHCBF, its main metabolite) hair concentrations were determined using a liquid chromatography-tandem mass spectrometry method. The obtained results were surprising if we consider several hair analyses previously published and based on a theory of the presence of xenobiotic in the only segment that comprised its intake. Among the two intoxication cases, we noticed the presence of CBF and OHCBF in hair segments corresponding to 45 days before, and more than 100 days after, the day of intoxication. Additionally, repeated hair samplings and subsequent analysis revealed a decrease of the carbofuran's concentration during the hair life.
我们呈现了两例通过毛发分析证实的、非致命的克百威（CBF）中毒案例。使用液相色谱-串联质谱法测定了毛发中的克百威和 3-羟基克百威（OHCBF，其主要代谢物）浓度。如果我们考虑到之前发表的几项基于摄入物仅在摄入的那一段存在的理论的毛发分析结果，那么获得的结果是令人惊讶的。在这两个中毒案例中，我们在中毒发生前 45 天和 100 多天后的毛发段中均发现了 CBF 和 OHCBF 的存在。此外，重复的毛发采样和后续分析显示，在毛发的生命周期中，克百威的浓度逐渐降低。
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