Organometallic Group, I & P C Division, Discovery Lab D-214, Indian Institute of Chemical Technology, Hyderabad, Uppal Road, Tarnaka, Hyderabad 500007, India.
Bioorg Med Chem Lett. 2011 Jul 1;21(13):3890-3. doi: 10.1016/j.bmcl.2011.05.036. Epub 2011 May 18.
A simple and efficient synthetic approach toward a series of chiral aryl boronate esters, starting from D-xylose, as anti-microbial agents, is described herein. Minimum inhibitory concentration and zone of inhibition revealed that these derivatives exhibit potent anti-bacterial and anti-fungal properties. Herein, we report the first anti-microbial activity of this class of compounds. All products have been characterized by NMR ((1)H, (13)C and (11)B), IR, elemental and mass spectral study.
本文描述了一种从 D-木糖出发，作为抗菌剂的一系列手性芳基硼酸酯的简单高效的合成方法。最低抑菌浓度和抑菌圈表明这些衍生物具有很强的抗细菌和抗真菌特性。本文首次报道了这类化合物的抗菌活性。所有产物均通过 NMR((1)H、(13)C 和 (11)B)、IR、元素分析和质谱研究进行了表征。
