Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, Poland.
Cytokine. 2011 Sep;55(3):353-61. doi: 10.1016/j.cyto.2011.05.006.
The presence of low-grade chronic inflammation is a known feature of long standing diabetes type 1. The association between serum level of several markers of inflammation and severity of DM1 was proven. Serum concentrations of TNF were reported to be elevated in diabetic patients, especially those who developed diabetic complications. Lately, it has been also shown that TNF may impair the subset of naturally arising regulatory T cells, which control autoimmunity. The presented study, for the first time, shows the regulatory T cells in the context of an inflammatory environment that is present in patients with type 1 diabetes. It indicates that TNF reduces the number and frequency of regulatory CD4(+)Foxp3(+) T cells in children with diabetes type 1 and that in vitro treatment with anti-TNF antibody seems to rescue this cell subset from its defective effects.
低度慢性炎症的存在是长期 1 型糖尿病的一个已知特征。已经证明了几种炎症标志物的血清水平与 DM1 严重程度之间的关联。据报道，糖尿病患者，特别是那些发生糖尿病并发症的患者，血清 TNF 浓度升高。最近，也表明 TNF 可能损害控制自身免疫的天然产生的调节性 T 细胞亚群。本研究首次在 1 型糖尿病患者中存在的炎症环境中展示了调节性 T 细胞。它表明 TNF 减少了 1 型糖尿病儿童调节性 CD4(+)Foxp3(+)T 细胞的数量和频率，并且体外用抗 TNF 抗体治疗似乎可以使该细胞亚群免受其缺陷作用的影响。
