1] Department of Infection and Immunity, Experimental and Molecular Immunology, Luxembourg Institute of Health, 29 rue Henri Koch, L-4354 Esch-sur-Alzette, Luxembourg. [2].
1] The Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2M9, Canada. [2].
Nat Rev Immunol. 2015 Jun;15(6):362-74. doi: 10.1038/nri3834.
Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) signalling is associated with many inflammatory disorders, including various types of arthritis and inflammatory bowel disease, and targeting TNF has been an effective therapeutic strategy in these diseases. This Review focuses on the recent advances that have been made in understanding TNFR signalling and the consequences of its deregulation for cellular survival, apoptosis and regulated necrosis. We discuss how TNF-induced survival signals are distinguished from those that lead to cell death. Finally, we provide a brief overview of the role of TNF in inflammatory and autoimmune diseases, and we discuss up-to-date and future treatment strategies for these disorders.
肿瘤坏死因子（TNF）是一种促炎细胞因子，在哺乳动物的免疫和细胞稳态中具有重要作用。TNF 受体（TNFR）信号的失调与许多炎症性疾病有关，包括各种类型的关节炎和炎症性肠病，针对 TNF 的治疗已成为这些疾病的有效治疗策略。这篇综述重点介绍了在理解 TNFR 信号及其失调对细胞存活、凋亡和调节性坏死的影响方面取得的最新进展。我们讨论了 TNF 诱导的存活信号与导致细胞死亡的信号之间的区别。最后，我们简要概述了 TNF 在炎症和自身免疫性疾病中的作用，并讨论了这些疾病的最新和未来的治疗策略。
