Dept. of Microbiology, Faculty of Sciences, University of Tehran, Enghelab Ave., Tehran 141556455, Iran.
Int J Med Microbiol. 2011 Aug;301(6):506-12. doi: 10.1016/j.ijmm.2011.03.002. Epub 2011 Jun 8.
The frequency of Helicobacter pylori vacA alleles, cagA, and jhp0947 and their association with types and advanced forms of gastritis in 143 first-degree relatives of gastric cancer (GC) patients was assessed. The subjects included 64/143 with antral-predominant gastritis, 68/143 with pangastritis, and 11/143 with corpus-predominant gastritis, with or without atrophy or intestinal metaplasia (IM). Further classification included the severity of atrophy or IM. Group I (40/143) included the subjects with moderate-marked atrophy or IM, group II (58/143) those with no atrophy or IM, and group III (45/143) with mild atrophy or IM. The frequency of vacA s1 was 79.7%, vacA s2 20.3%, m1 49.7%, m2 50.3%, cagA 76.2%, and jhp0947 58%. The most prevalent combination was vacAs1 cagA (+) (65.7%) (P=0.001). Of the 143 subjects, 85 (59.4%) showed atrophy or IM, and 40/85 (47%) developed the moderate-marked atrophy or IM. No significant correlation was found between genotypes and the types of gastritis, non-atrophy, atrophy, or IM and severe forms of atrophy or IM (P>0.05). It is proposed that H. pylori genotype status might not be considered as an important determinant of the types and advanced forms of gastritis in the first-degree relatives of GC patients.
研究了 143 例胃癌（GC）患者一级亲属中幽门螺杆菌 vacA 等位基因、cagA 和 jhp0947 的频率及其与胃炎类型和进展形式的关系。受试者包括 64/143 例胃窦为主的胃炎、68/143 例全胃炎和 11/143 例胃体为主的胃炎，伴有或不伴有萎缩或肠化生（IM）。进一步分类包括萎缩或 IM 的严重程度。第 I 组（40/143）包括中重度萎缩或 IM 的患者，第 II 组（58/143）包括无萎缩或 IM 的患者，第 III 组（45/143）包括轻度萎缩或 IM 的患者。vacA s1 的频率为 79.7%，vacA s2 为 20.3%，m1 为 49.7%，m2 为 50.3%，cagA 为 76.2%，jhp0947 为 58%。最常见的组合是 vacAs1 cagA（+）（65.7%）（P=0.001）。在 143 例患者中，85 例（59.4%）出现萎缩或 IM，其中 40/85 例（47%）发生中重度萎缩或 IM。基因型与胃炎类型、非萎缩、萎缩或 IM 以及严重形式的萎缩或 IM 之间无显著相关性（P>0.05）。因此，H. pylori 基因型可能不能作为 GC 患者一级亲属胃炎类型和进展形式的重要决定因素。
