Nalini K, Andrabi K I, Ganguly N K, Wahi P L
Department of Cardiology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Mol Cell Biochem. 1990 Jun 25;95(2):133-7. doi: 10.1007/BF00219971.
Administration of Ca2+ channel blockers in cardiac disorders and the central role of Ca2+ in modulating neutrophil functions, prompted us to investigate whether administration of nifedipine to mice would alter their natural resistance to infectious agents like Salmonella typhimurium. Neutrophil chemiluminescence (CL) in response to S. typhimurium was significantly (p less than 0.01) decreased in mice fed with nifedipine (0.015 mg/kg body weight) over a period of six months. Intracellular killing of S. typhimurium by isolated neutrophils also decreased significantly (p less than 0.01) and exponentially with nifedipine administration, representing a 42% fall at six months. In addition the drug administration lowered the survival rate of animals following challenge by a lethal dose of S. typhimurium (LD50 = 1 x 10(4) bacteria/animal). Our data suggest that long term administration of nifedipine lowers the natural resistance of mice to S. typhimurium owing to impaired neutrophil functions.
在心脏疾病中使用钙通道阻滞剂以及钙在调节中性粒细胞功能中的核心作用，促使我们研究给小鼠服用硝苯地平是否会改变它们对鼠伤寒沙门氏菌等感染因子的天然抵抗力。在六个月的时间里，给喂食硝苯地平（0.015毫克/千克体重）的小鼠注射鼠伤寒沙门氏菌后，中性粒细胞化学发光（CL）显著降低（p小于0.01）。分离出的中性粒细胞对鼠伤寒沙门氏菌的细胞内杀伤作用也随着硝苯地平给药而显著降低（p小于0.01）且呈指数下降，六个月时下降了42%。此外，给药降低了动物在接受致死剂量鼠伤寒沙门氏菌（LD50 = 1×10⁴个细菌/动物）攻击后的存活率。我们的数据表明，长期服用硝苯地平会因中性粒细胞功能受损而降低小鼠对鼠伤寒沙门氏菌的天然抵抗力。
