环孢素预处理对玻璃化冷冻牛成熟卵母细胞线粒体功能的影响。
Effect of cyclosporine pretreatment on mitochondrial function in vitrified bovine mature oocytes.
机构信息
Embryo Biotechnology and Reproduction Laboratory, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, People's Republic of China.
出版信息
Fertil Steril. 2011 Jun 30;95(8):2786-8. doi: 10.1016/j.fertnstert.2011.04.089. Epub 2011 Jun 8.
Abstract
Vitrification had a significantly negative impact on the mitochondrial function of bovine oocytes. However, 40 μg/mL cyclosporine pretreatment before vitrification contributed greatly to maintaining mitochondrial membrane potential and adenosine triphosphate content, decreasing reactive oxygen species level, and thereby increasing the developmental ability of vitrified oocytes.
摘要
玻璃化冷冻对牛卵母细胞的线粒体功能有显著的负面影响。然而，玻璃化冷冻前用 40μg/ml 的环孢素预处理可以极大地帮助维持线粒体膜电位和三磷酸腺苷含量，降低活性氧水平，从而提高玻璃化冷冻卵母细胞的发育能力。
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