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年龄并不影响胚胎碎片对囊胚发育成功的影响。

Age does not influence the effect of embryo fragmentation on successful blastocyst development.

机构信息

Center for Reproductive Health, University of Cincinnati Academic Health Center, Cincinnati, Ohio 45219, USA.

出版信息

Fertil Steril. 2011 Jun 30;95(8):2778-80. doi: 10.1016/j.fertnstert.2011.05.024. Epub 2011 Jun 8.

DOI:10.1016/j.fertnstert.2011.05.024
PMID:21641595
Abstract

We evaluated the rate of blastocyst development in day 3 embryos with appropriate cellular division and investigated whether maternal age modified the effect of embryo fragmentation on blastulation. Our data showed a significant negative correlation between the degree of embryo fragmentation and rate of blastocyst development, but age did not exert an effect on the degree of fragmentation in embryos with appropriate cleaving status, nor did it modify the significant effect embryo fragmentation had on blastocyst formation.

摘要

我们评估了具有适当细胞分裂的第 3 天胚胎的囊胚发育率,并研究了母体年龄是否改变了胚胎碎片对囊胚形成的影响。我们的数据显示,胚胎碎片的程度与囊胚发育率之间存在显著的负相关,但年龄对具有适当分裂状态的胚胎的碎片程度没有影响,也没有改变胚胎碎片对囊胚形成的显著影响。

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1
Age does not influence the effect of embryo fragmentation on successful blastocyst development.年龄并不影响胚胎碎片对囊胚发育成功的影响。
Fertil Steril. 2011 Jun 30;95(8):2778-80. doi: 10.1016/j.fertnstert.2011.05.024. Epub 2011 Jun 8.
2
Human blastocyst morphological quality is significantly improved in embryos classified as fast on day 3 (>or=10 cells), bringing into question current embryological dogma.在第3天被归类为快速发育(≥10个细胞)的胚胎中,人类囊胚的形态质量显著提高,这对当前的胚胎学教条提出了质疑。
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Embryo fragmentation as a determinant of blastocyst development in vitro and pregnancy outcomes following embryo transfer.胚胎碎片作为体外囊胚发育及胚胎移植后妊娠结局的一个决定因素。
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Late stages of embryo progression are a much better predictor of clinical pregnancy than early cleavage in intracytoplasmic sperm injection and in vitro fertilization cycles with blastocyst-stage transfer.在卵胞浆内单精子注射以及进行囊胚期移植的体外受精周期中,胚胎发育的后期阶段比早期卵裂情况更能准确预测临床妊娠。
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Defragmentation of low grade day 3 embryos resulted in sustained reduction in fragmentation, but did not improve compaction or blastulation rates.将低等级第三天胚胎进行碎片化处理,可导致碎片持续减少,但不能提高胚胎的致密化或囊胚形成率。
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引用本文的文献

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Effect of cytoplasmic fragmentation on embryo development, quality, and pregnancy outcome: a systematic review of the literature.细胞质碎片化对胚胎发育、质量和妊娠结局的影响:文献系统综述。
Reprod Biol Endocrinol. 2024 May 14;22(1):55. doi: 10.1186/s12958-024-01217-7.
2
Human metaphase II oocytes with narrow perivitelline space have poor fertilization, developmental, and pregnancy potentials.卵周隙狭窄的人类中期 II 期卵母细胞受精、发育及妊娠潜力较差。
J Assist Reprod Genet. 2024 May;41(5):1449-1458. doi: 10.1007/s10815-024-03084-y. Epub 2024 Mar 19.
3
Embryo blastulation and quality between days 5 and 6 of extended embryo culture.
胚胎囊胚培养和第 5-6 天的胚胎质量。
J Assist Reprod Genet. 2021 Aug;38(8):2193-2198. doi: 10.1007/s10815-021-02156-7. Epub 2021 Mar 22.
4
Single-cell sequencing of primate preimplantation embryos reveals chromosome elimination via cellular fragmentation and blastomere exclusion.灵长类动物植入前胚胎的单细胞测序揭示了通过细胞碎裂和卵裂球排除实现的染色体消除。
Genome Res. 2019 Mar;29(3):367-382. doi: 10.1101/gr.239830.118. Epub 2019 Jan 25.