Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Atherosclerosis. 2011 Sep;218(1):226-32. doi: 10.1016/j.atherosclerosis.2011.05.009. Epub 2011 May 18.
Postprandial hyperlipidemia (PPHL) is an independent risk factor for coronary heart disease (CHD) which is based on the accumulation of chylomicrons (CM) and CM remnants containing apolipoprotein B-48 (apoB-48). Since atherosclerotic cardiovascular diseases are frequently observed even in subjects with normal serum triglyceride (TG) level, the correlation between fasting apoB-48 containing lipoproteins and carotid intima-media thickness (IMT) was analyzed in subjects with normal TG levels.
From subjects who took their annual health check at the Osaka Police Hospital (n=245, male), one-hundred and sixty-four male subjects were selected to take part in this study; the excluding factors were: systolic blood pressure ≥ 140 mmHg, intake of antihypertensive or antihyperlipidemic drugs, or age >65 years. The association between biochemical markers and IMT was analyzed and independent predictors of max-IMT were determined by multiple regression analysis in all subjects and in groups N-1 (TG<100mg/dl, n=58), N-2 (100 ≤ TG<150 mg/dl, n=53) and H (150 ≤ TG mg/dl, n=53), respectively.
Fasting total cholesterol, LDL-cholesterol, HDL-cholesterol, apoB-100 and lnRemL-C (remnant lipoprotein-cholesterol) levels were not correlated with max-IMT, but lnTG and lnapoB-48 were significantly correlated with max-IMT in all subjects. LnapoB-48 and apoB-48/TG ratio were significantly correlated with max-IMT in group N-2. By multiple regression analysis, age and lnapoB-48 were independent variables associated with max-IMT in group N-2.
Serum apoB-48 level might be a good marker for the detection of early atherosclerosis in middle-aged subjects with normal-range levels of blood pressure and TG.
餐后高脂血症（PPHL）是冠心病（CHD）的独立危险因素，这是基于乳糜微粒（CM）和含有载脂蛋白 B-48（apoB-48）的 CM 残基的积累。由于即使在血清甘油三酯（TG）水平正常的患者中也经常观察到动脉粥样硬化性心血管疾病，因此分析了 TG 水平正常的患者空腹含 apoB-48 的脂蛋白与颈动脉内膜中层厚度（IMT）之间的相关性。
从在大阪警察医院进行年度健康检查的受试者（n=245，男性）中，选择了 164 名男性受试者参加本研究；排除因素包括：收缩压≥140mmHg、服用降压或降脂药物或年龄>65 岁。对所有受试者和 N-1 组（TG<100mg/dl，n=58）、N-2 组（100≤TG<150mg/dl，n=53）和 H 组（150≤TGmg/dl，n=53）分别分析生化标志物与 IMT 的相关性，并通过多元回归分析确定 max-IMT 的独立预测因子。
空腹总胆固醇、LDL-胆固醇、HDL-胆固醇、apoB-100 和 lnRemL-C（残脂蛋白胆固醇）水平与 max-IMT 无相关性，但所有受试者的 lnTG 和 lnapoB-48 与 max-IMT 显著相关。在 N-2 组中，lnapoB-48 和 apoB-48/TG 比值与 max-IMT 显著相关。通过多元回归分析，年龄和 lnapoB-48 是 N-2 组与 max-IMT 相关的独立变量。
血清 apoB-48 水平可能是检测血压和 TG 水平正常的中年患者早期动脉粥样硬化的良好标志物。
