Karasek David, Vaverkova Helena, Halenka Milan, Jackuliakova Dagmar, Frysak Zdenek, Orsag Jiri, Novotny Dalibor
Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, University Hospital Olomouc, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013 Mar;157(1):41-9. doi: 10.5507/bp.2012.046. Epub 2012 Jun 1.
Like hypertension, prehypertension is associated with cardiovascular disease.
The aim of this study was to evaluate: a) the prevalence of prehypertension/hypertension in individuals with various dyslipidemic phenotypes; b) the relation between blood pressure (BP) and other risk factors for atherosclerosis; c) atherogenic potential of prehypertension by the assessment of intima-media thickness of the arteria carotis communis (IMT).
667 clinically asymptomatic subjects were divided into four dyslipidemic phenotypes (DLP) according to apolipoprotein B (apoB) and triglycerides (TG): DLP1 (n=198, normo-apoB/normo-TG), DLP2 (n=179, normo-apoB/hyper-TG), DLP3 (n=87, hyper-apoB/normo-TG), DLP4 (n=203, hyper-apoB/hyper-TG). DLP1 served as a control group.
There was significantly higher prevalence of prehypertension and hypertension in subjects with dyslipidemia (DLP2 43.0%, 41.3%; DLP3 42.5%, 29.9%; DLP4 42.4%, 47.8%) than in normolipidemic individuals (DLP1 32.8%, 20.2%). Systolic and diastolic blood pressure (SBP + DBP) correlated with age, total cholesterol, TG, non-HDL-cholesterol, body mass index and waist circumference; SBP additionally with C-peptide, fasting glycemia; DBP additionally with apoB, homeostasis model assessment (HOMA) and plasminogen activator inhibitor-1. The IMT of hypertensive and of prehypertensive subjects was higher than that of subjects with normal BP in all DLPs.
The prevalence of prehypertension was higher in all dyslipidemic patients. The common prevalence of prehypertension/hypertension was highest in the hypertriglyceridemic subjects. Prehypertensive and hypertensive patients had higher IMT than normotensive individuals in all DLPs.
与高血压一样，血压正常高值也与心血管疾病相关。
本研究旨在评估：a）不同血脂异常表型个体中血压正常高值/高血压的患病率；b）血压（BP）与动脉粥样硬化其他危险因素之间的关系；c）通过评估颈总动脉内膜中层厚度（IMT）来评估血压正常高值的致动脉粥样硬化潜力。
667名临床无症状受试者根据载脂蛋白B（apoB）和甘油三酯（TG）被分为四种血脂异常表型（DLP）：DLP1（n = 198，正常apoB/正常TG），DLP2（n = 179，正常apoB/高TG），DLP3（n = 87，高apoB/正常TG），DLP4（n = 203，高apoB/高TG）。DLP1作为对照组。
血脂异常患者（DLP2为43.0%，41.3%；DLP3为42.5%，29.9%；DLP4为42.4%，47.8%）中血压正常高值和高血压的患病率显著高于血脂正常个体（DLP1为32.8%，20.2%）。收缩压和舒张压（SBP + DBP）与年龄、总胆固醇、TG、非高密度脂蛋白胆固醇、体重指数和腰围相关；SBP还与C肽、空腹血糖相关；DBP还与apoB、稳态模型评估（HOMA）和纤溶酶原激活物抑制剂-1相关。在所有DLP中，高血压和血压正常高值受试者的IMT均高于血压正常受试者。
所有血脂异常患者中血压正常高值的患病率更高。高甘油三酯血症受试者中血压正常高值/高血压的总体患病率最高。在所有DLP中，血压正常高值和高血压患者的IMT均高于血压正常个体。
