Guzman J, Kraft A, Bross K J, Würtemberger G, Costabel U
Pathologisches Institut und Medizinische Klinik der Universität Freiburg.
Pneumologie. 1990 Feb;44 Suppl 1:601-2.
In pleural effusions, histologically proven to be malignant in 13 patients with small cell lung cancer, the immunocytological profile of tumour cells, together with the distribution of the lymphocyte subpopulations, were established. In all cases, tumor cells were demonstrable with the monoclonal antibodies EMA, HEA-125, Sam 2, 6, 8 and 10. In contrast, conventional cytology was positive in only 6 of the 13 cases. As in other malignant or inflammatory effusions, phenotyping of the lymphocytes revealed an elevated T4/T8 ratio in comparison with the normal value for peripheral blood.
在13例经组织学证实为小细胞肺癌的胸腔积液患者中，确定了肿瘤细胞的免疫细胞特征以及淋巴细胞亚群的分布。在所有病例中，肿瘤细胞均可被单克隆抗体EMA、HEA - 125、Sam 2、6、8和10检测到。相比之下，传统细胞学检查在13例中仅6例呈阳性。与其他恶性或炎性积液一样，淋巴细胞表型分析显示，与外周血正常值相比，T4/T8比值升高。
