Corbier P, Roffi J
Biol Neonate. 1978;34(3-4):105-11. doi: 10.1159/000241113.
During the first hours of post-natal life, the newborn rat does not respond to ether stress by a rapid increase of ACTH secretion. Ether inhalation by 5- and 12-hour-old animals slightly but significantly increases plasma and adrenal corticosterone levels, but only 30 min after the onset of stress. At 1 day of age, adrenal response is established. The adrenal cortex of 5-hour-old animals responds normally to an intraperitoneal injection of 25 mU of ACTH. These results indicate that there is an absolute stress non-response period in newborn rats which is followed by a relative stress non-response period. The lack of response is not due to an organic block of the adrenal cortex, but could be due to the accumulation of elevated levels of corticosterone in the central nervous system.
在出生后的最初几个小时内，新生大鼠不会因乙醚应激而使促肾上腺皮质激素（ACTH）分泌迅速增加。对5小时和12小时大的动物进行乙醚吸入，可使血浆和肾上腺皮质酮水平略有但显著升高，但仅在应激开始后30分钟出现。在出生1天时，肾上腺反应已建立。5小时大动物的肾上腺皮质对腹腔注射25 mU的ACTH反应正常。这些结果表明，新生大鼠存在一个绝对应激无反应期，随后是一个相对应激无反应期。反应缺失并非由于肾上腺皮质的器质性阻滞，而可能是由于中枢神经系统中皮质酮水平升高的积累所致。
