自发性高血压大鼠松果体中磷酸肌醇水解增强。

Enhanced phosphoinositide hydrolysis in the pineal gland of spontaneously hypertensive rats.

作者信息

Laitinen J T, Torda T, Saavedra J M

机构信息

Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892.

出版信息

Am J Hypertens. 1990 Jun;3(6 Pt 1):496-8. doi: 10.1093/ajh/3.6.496.

DOI:10.1093/ajh/3.6.496

PMID:2164402

Abstract

We studied the phosphoinositide (PI) turnover in the pineal gland of spontaneously hypertensive rats (SHR) and compared it to that in Wistar-Kyoto and Wistar rats. Both basal and norepinephrine-stimulated PI turnover were significantly higher in the SHR than in the other strains. Prazosin (1 mumol/L) completely blocked the norepinephrine-induced PI hydrolysis in all groups. However, prazosin failed to lower the enhanced basal PI turnover in SHR. Pineal response to the cholinergic agonist carbachol was similar in all groups. These results suggest enhanced membrane phospholipid turnover in the pineal gland of SHR. Moreover, signaling via the alpha 1-adrenoceptor might be sensitized in the SHR.

摘要

我们研究了自发性高血压大鼠（SHR）松果体中的磷酸肌醇（PI）周转情况，并将其与Wistar-Kyoto大鼠和Wistar大鼠进行比较。SHR的基础和去甲肾上腺素刺激的PI周转均显著高于其他品系。哌唑嗪（1 μmol/L）完全阻断了所有组中去甲肾上腺素诱导的PI水解。然而，哌唑嗪未能降低SHR中增强的基础PI周转。所有组中松果体对胆碱能激动剂卡巴胆碱的反应相似。这些结果表明SHR松果体中的膜磷脂周转增强。此外，SHR中通过α1-肾上腺素能受体的信号传导可能被致敏。