Wen H L, Ng Y H, Ho W K, Fung K P, Wong H K, Ma L, Wong H C
Bull Narc. 1978 Apr-Jun;30(2):31-9.
Eight female heroin-addicted subjects were treated over a 10-day period by acupuncture and electrical stimulation (AES). Their plasma ACTH, cortisol and c-AMP levels were reduced after initial AES treatment. The reduction of c-AMP was significant the most of the three. The suppression of these compounds may be associated with the temporary relief of withdrawl symptoms on and after each AES treatment in the first three days. On the third day, ACTH, cortisol and c-AMP levels did not show significant changes after AES. This was presumably due to the disappearance of withdrawal symptoms and possibly to the stabilizing effect of the treatment. Both the ACTH and c-AMP levels were generally lower at the end of the treatment period. Results of the present investigation suggest that plasma c-AMP may be the best parameter by which to gauge the response of heroin addicts to AES.
八名女性海洛因成瘾者在10天的时间里接受了针刺和电刺激（AES）治疗。初次AES治疗后，她们的血浆促肾上腺皮质激素（ACTH）、皮质醇和环磷酸腺苷（c-AMP）水平降低。c-AMP的降低在这三者中最为显著。这些化合物的抑制可能与最初三天每次AES治疗时及治疗后的戒断症状暂时缓解有关。在第三天，AES治疗后ACTH、皮质醇和c-AMP水平未显示出显著变化。这可能是由于戒断症状消失以及治疗的稳定作用。在治疗期结束时，ACTH和c-AMP水平总体上较低。本研究结果表明，血浆c-AMP可能是衡量海洛因成瘾者对AES反应的最佳参数。
