Harlow B L, Weiss N S, Holmes E H
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Cancer Res. 1990 Aug 1;50(15):4702-3.
The authors obtained venous blood samples from 106 female residents of western Washington in whom serous and mucinous borderline ovarian tumors had been diagnosed between 1980 and 1985 ("cases") and from a randomly selected telephone sample of 134 control women from the same counties. Mean activity in plasma of alpha-L-fucosidase was slightly higher in cases (334 units/ml) compared to controls (306 units/ml). The risk for a serous borderline tumor was virtually the same for women in all four quartiles of alpha-L-fucosidase activity. Women in the three lowest quartiles of activity were at 50-70% the risk of women in the highest quartile for the development of a mucinous tumor, but within these three quartiles there was no trend of decreasing risk with decreasing activity. These results suggest that for most women plasma alpha-L-fucosidase activity has little or no bearing on the risk of borderline ovarian tumors. Whether such an association exists in women genetically predisposed to these tumors could not be assessed.
作者从106名华盛顿州西部的女性居民中采集了静脉血样本，这些女性在1980年至1985年间被诊断出患有浆液性和黏液性交界性卵巢肿瘤（“病例组”），并从同一县随机抽取的134名对照女性的电话样本中采集了血样。病例组血浆中α-L-岩藻糖苷酶的平均活性（334单位/毫升）略高于对照组（306单位/毫升）。对于α-L-岩藻糖苷酶活性的所有四个四分位数中的女性，患浆液性交界性肿瘤的风险几乎相同。活性处于最低三个四分位数的女性患黏液性肿瘤的风险是最高四分位数女性的50%-70%，但在这三个四分位数范围内，风险并没有随着活性降低而呈下降趋势。这些结果表明，对于大多数女性来说，血浆α-L-岩藻糖苷酶活性与交界性卵巢肿瘤的风险几乎没有关系。在遗传易患这些肿瘤的女性中是否存在这种关联无法评估。
