手性腈的结构变化对铑催化炔烃硅氢化反应立体选择性的影响
Switch in stereoselectivity caused by the isocyanide structure in the rhodium-catalyzed silylimination of alkynes.
机构信息
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
J Am Chem Soc. 2011 Jul 6;133(26):10014-7. doi: 10.1021/ja202881y. Epub 2011 Jun 13.
PMID:21644512
Abstract
The reaction of terminal alkynes with hydrosilanes and tert-alkyl isocyanides in the presence of Rh(4)(CO)(12) gives (Z)-β-silyl-α,β-unsaturated imines in good yields. On the other hand, the use of aryl isocyanides in place of tert-alkyl isocyanides leads to the formation of E isomers.
摘要
在 Rh(4)(CO)(12)的存在下，末端炔与氢硅烷和叔烷基异氰化物的反应以良好的收率得到(Z)-β-硅基-α,β-不饱和亚胺。另一方面，用芳基异氰化物代替叔烷基异氰化物会导致形成 E 异构体。
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