连续缩合、C-N 和 N-N 键形成：一锅法三组分合成 2H-吲唑的铜催化反应。
Consecutive condensation, C-N and N-N bond formations: a copper- catalyzed one-pot three-component synthesis of 2H-indazole.
机构信息
Department of Chemistry and Institute of Basic Science, Chonnam National University, Gwangju, 500-757, Republic of Korea.
出版信息
Org Lett. 2011 Jul 1;13(13):3542-5. doi: 10.1021/ol201409j. Epub 2011 Jun 6.
PMID:21644532
Abstract
2H-Indazoles are synthesized using copper-catalyzed, one-pot, three-component reactions of 2-bromobenzaldehydes, primary amines, and sodium azide. A copper catalyst plays the key role in the formation of C-N and N-N bonds. This method has a broad substrate scope with a high tolerance for a variety of functional groups.
摘要
2H-吲唑是通过铜催化的一锅法、三组分反应，由 2-溴苯甲醛、伯胺和叠氮化钠合成得到的。铜催化剂在 C-N 和 N-N 键的形成中起着关键作用。该方法具有广泛的底物范围，对各种官能团具有很高的容忍度。
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