Tang D G, Tian H S
Department of Pathology, Hubei Medical College, Wuhan.
Chin Med J (Engl). 1990 Mar;103(3):208-15.
The effects of prostaglandin E1(PGE1), prostaglandin synthesis inhibitor and indomethacin (IN) on the growth and metastasis of Lewis lung carcinoma (LLC) were studied and their mechanisms of action were investigated. Seventy-five C57BL mice of both sexes were utilized in the experiment. It was found that both PGE1 and IN could significantly retard the growth of transplanted LLC and reduce the number of pulmonary metastatic foci. PGE1 obviously decreased the acid phosphatase (ACP) activity of LLC cells while IN showed no such effect. Besides, PGE1 could markedly elevate the plasma cAMP level of LLC-bearing mice, but not normal controls. Meanwhile, it could decrease plasma cGMP concentration of both normal and tumor-bearing mice. IN, like PGE1, could increase plasma cAMP and decrease plasma cGMP levels of LLC-bearing animals. TEM observation revealed that tumor cells treated with PGE1 and IN presented a series of degenerative and destructive changes. In addition, PGE1 and IN exhibited a different effect on several cell-mediated immune responses of the tumored hosts, the former inhibitory and the latter stimulatory. The possible mechanisms of action of the two chemicals are discussed.
研究了前列腺素E1（PGE1）、前列腺素合成抑制剂和吲哚美辛（IN）对Lewis肺癌（LLC）生长和转移的影响，并探讨了其作用机制。实验选用75只雌雄C57BL小鼠。结果发现，PGE1和IN均可显著抑制移植性LLC的生长，并减少肺转移灶的数量。PGE1明显降低了LLC细胞的酸性磷酸酶（ACP）活性，而IN则无此作用。此外，PGE1可显著提高荷LLC小鼠的血浆cAMP水平，但对正常对照组无此作用。同时，它可降低正常小鼠和荷瘤小鼠的血浆cGMP浓度。IN与PGE1一样，可提高荷LLC动物的血浆cAMP水平并降低血浆cGMP水平。透射电镜观察显示，经PGE1和IN处理的肿瘤细胞呈现出一系列退行性和破坏性变化。此外，PGE1和IN对荷瘤宿主的几种细胞介导的免疫反应表现出不同的作用，前者具有抑制作用，后者具有刺激作用。讨论了这两种化学物质可能的作用机制。
