Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, Alabama 35487, United States.
Langmuir. 2011 Jul 19;27(14):8990-7. doi: 10.1021/la201652h. Epub 2011 Jun 16.
The water dispensability and stability of high quality iron oxide nanoparticles synthesized in organic solvents are major issues for biomedical and biological applications. In this paper, a versatile approach for preparing water-soluble iron oxide nanoparticles with great stability and selective surface functionality (-COOH, -NH(2), or -SH) was demonstrated. The hydrophobic nanoparticles were first synthesized by the thermal decomposition of an iron oleate complex in organic solvent. Subsequently, the hydrophobic coatings of nanoparticles were replaced with poly(acrylic acid) , polyethylenimine, or glutathione, yielding charged nanoparticles in aqueous solution. Two parameters were found to be critical for obtaining highly stable nanoparticle dispersions: the original coating and the surfactant-to-nanoparticle ratio. These charged nanoparticles exhibited different stabilities in biological buffers, which were directly influenced by the surface coatings. This report will provide significant practical value in exploring the biological or biomedical applications of iron oxide nanoparticles.
有机溶剂中合成的高质量氧化铁纳米粒子的水分散性和稳定性是生物医学和生物学应用的主要问题。本文提出了一种通用的方法，用于制备具有高稳定性和选择性表面功能（-COOH、-NH(2)或-SH）的水溶性氧化铁纳米粒子。首先通过在有机溶剂中热分解油酸铁络合物合成疏水性纳米粒子。随后，用聚丙烯酸、聚乙烯亚胺或谷胱甘肽取代纳米粒子的疏水性涂层，在水溶液中得到带电荷的纳米粒子。发现有两个参数对于获得高度稳定的纳米粒子分散体非常关键：原始涂层和表面活性剂与纳米粒子的比例。这些带电荷的纳米粒子在生物缓冲液中的稳定性不同，这直接受到表面涂层的影响。本报告将为探索氧化铁纳米粒子的生物或医学应用提供重要的实际价值。
