• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

米氮平治疗抑郁症的应用评价。

Review of the use of mirtazapine in the treatment of depression.

机构信息

Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Box 3837, Durham, NC 27710, USA.

出版信息

Expert Opin Pharmacother. 2011 Jul;12(10):1623-32. doi: 10.1517/14656566.2011.585459. Epub 2011 Jun 6.

DOI:10.1517/14656566.2011.585459
PMID:21644844
Abstract

INTRODUCTION

Depression is a heterogeneous illness affecting large numbers of patients with far reaching effects on both psychiatric and medical outcomes as well as quality of life. Knowledge about the different treatment modalities used to treat depression is important to all physicians.

AREAS COVERED

This article expands on one such treatment option, mirtazapine. The paper examines this medication's medicinal chemistry, pharmacological properties as well as the efficacy of the medication compared to other commonly used antidepressants.

EXPERT OPINION

Mirtazapine is a medication unlike other agents used for depression both in its mechanism of action as well as its side effects. Knowing these distinct characteristics will enable physicians to better utilize this agent for the benefit of their patients.

摘要

简介

抑郁症是一种影响大量患者的异质性疾病,对精神和医疗结果以及生活质量都有深远的影响。了解治疗抑郁症的不同方法对所有医生都很重要。

涵盖领域

本文扩展了一种这样的治疗选择,即米氮平。本文研究了这种药物的药物化学、药理学特性以及与其他常用抗抑郁药相比的疗效。

专家意见

米氮平是一种与其他用于治疗抑郁症的药物不同的药物,无论是在作用机制还是副作用方面。了解这些独特的特征将使医生能够更好地利用这种药物为患者带来好处。

相似文献

1
Review of the use of mirtazapine in the treatment of depression.米氮平治疗抑郁症的应用评价。
Expert Opin Pharmacother. 2011 Jul;12(10):1623-32. doi: 10.1517/14656566.2011.585459. Epub 2011 Jun 6.
2
Mirtazapine: a newer antidepressant.米氮平:一种新型抗抑郁药。
Am Fam Physician. 1999 Jan 1;59(1):159-61.
3
A risk-benefit assessment of mirtazapine in the treatment of depression.米氮平治疗抑郁症的风险效益评估。
Drug Saf. 1997 Oct;17(4):251-64. doi: 10.2165/00002018-199717040-00005.
4
[Mirtazapine--the new standard].
Fortschr Neurol Psychiatr. 1999 Aug;67(8 Suppl):1-4.
5
Venlafaxine plus mirtazapine as first-line treatment for melancholia: preliminary results.文拉法辛联合米氮平作为忧郁症的一线治疗:初步结果
J Psychopharmacol. 2010 Dec;24(12):1837. doi: 10.1177/0269881110376696.
6
[Mirtazapine versus other antidepressive agents for depression].[米氮平与其他抗抑郁药治疗抑郁症的比较]
Ugeskr Laeger. 2012 Nov 12;174(46):2864-6.
7
Effect of mirtazapine versus fluoxetine on "sleep quality".米氮平与氟西汀对“睡眠质量”的影响。
J Clin Psychiatry. 2004 Aug;65(8):1149-50. doi: 10.4088/jcp.v65n0818i.
8
Selection of an antidepressant: mirtazapine.抗抑郁药的选择:米氮平。
J Clin Psychiatry. 1997;58 Suppl 6:3-8.
9
Mechanism of action of mirtazapine: dual action or dual effect?米氮平的作用机制:双重作用还是双重效应?
Aust N Z J Psychiatry. 2004 Apr;38(4):267-9; author reply 269. doi: 10.1080/j.1440-1614.2004.01348.x.
10
Anxiety and depression after lung transplantation: Mirtazapine as a first-choice agent?肺移植后的焦虑与抑郁:米氮平作为首选药物?
J Psychosom Res. 2007 Jan;62(1):101. doi: 10.1016/j.jpsychores.2006.10.019.

引用本文的文献

1
Mirtazapine revisited: new therapeutic perspectives and formulation advances.米氮平再审视:新的治疗前景与剂型进展
Naunyn Schmiedebergs Arch Pharmacol. 2025 Aug 23. doi: 10.1007/s00210-025-04525-w.
2
Optimizing therapeutic drug monitoring of mirtazapine - applying therapeutic reference range, concentration-dose ratio/dose-related concentration, and metabolic ratio in a naturalistic setting.优化米氮平的治疗药物监测——在实际环境中应用治疗参考范围、浓度-剂量比/剂量相关浓度和代谢比
Eur J Clin Pharmacol. 2025 Aug 20. doi: 10.1007/s00228-025-03907-6.
3
Mirtazapine in pregnancy and lactation: A systematic review of adverse outcomes.
米氮平在妊娠和哺乳期的应用:不良结局的系统评价
Acta Psychiatr Scand. 2025 Jan;151(1):6-32. doi: 10.1111/acps.13749. Epub 2024 Aug 31.
4
Major depressive disorder: hypothesis, mechanism, prevention and treatment.重度抑郁症:假说、机制、预防与治疗。
Signal Transduct Target Ther. 2024 Feb 9;9(1):30. doi: 10.1038/s41392-024-01738-y.
5
Pharmacological update of mirtazapine: a narrative literature review.米氮平的药理学更新:文献叙事综述。
Naunyn Schmiedebergs Arch Pharmacol. 2024 May;397(5):2603-2619. doi: 10.1007/s00210-023-02818-6. Epub 2023 Nov 9.
6
Identifying the Subtypes of Major Depressive Disorder Based on Somatic Symptoms: A Longitudinal Study Using Latent Profile Analysis.基于躯体症状识别重度抑郁症的亚型:一项使用潜在类别分析的纵向研究。
Front Psychiatry. 2022 Jul 12;13:759334. doi: 10.3389/fpsyt.2022.759334. eCollection 2022.
7
The molecular pathophysiology of depression and the new therapeutics.抑郁症的分子病理生理学与新疗法
MedComm (2020). 2022 Jul 21;3(3):e156. doi: 10.1002/mco2.156. eCollection 2022 Sep.
8
Mirtazapine exposure in pregnancy and fetal safety: A nationwide cohort study.米氮平暴露于妊娠及其胎儿安全性:一项全国性队列研究。
Acta Psychiatr Scand. 2022 Jun;145(6):557-567. doi: 10.1111/acps.13431. Epub 2022 Apr 1.
9
Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants.星形胶质细胞 5-羟色胺受体作为经典抗抑郁药的中枢靶点。
Adv Neurobiol. 2021;26:317-347. doi: 10.1007/978-3-030-77375-5_13.
10
A randomized, double-blind, placebo-controlled study to assess efficacy of mirtazapine for the treatment of diarrhea predominant irritable bowel syndrome.一项评估米氮平治疗腹泻型肠易激综合征疗效的随机、双盲、安慰剂对照研究。
Biopsychosoc Med. 2021 Feb 3;15(1):3. doi: 10.1186/s13030-021-00205-2.