电诱导豚鼠回肠释放内源性阿片受体配体的钙需求。
Calcium requirements for electrically-induced release of an endogenous opiate receptor ligand from the guinea-pig ileum.
作者信息
Oka T, Sawa A
出版信息
Br J Pharmacol. 1979 Jan;65(1):3-5. doi: 10.1111/j.1476-5381.1979.tb17326.x.
Abstract
Calcium requirements for electrically-induced release of an endogenous opiate receptor ligand in the myenteric plexus-longitudinal muscle strip of the guinea-pig ileum were studied. The naloxone-reversible depression of the electrically evoked contraction caused by stimulation at 10 Hz in normal Krebs solution was markedly reduced by decreasing the calcium concentration in the solution. The depression was greatly diminished by increasing the magnesium concentration in the solution. These results show that the electrically-induced release of an opiate-like material requires calcium ions.
摘要
研究了豚鼠回肠肌间神经丛-纵行肌条中内源性阿片受体配体电诱导释放的钙需求。在正常 Krebs 溶液中，10Hz 刺激引起的电诱发收缩的纳洛酮可逆性抑制，通过降低溶液中的钙浓度而显著降低。通过增加溶液中的镁浓度，这种抑制作用大大减弱。这些结果表明，阿片样物质的电诱导释放需要钙离子。
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