氟哌利多对豚鼠回肠内源性阿片肽生物合成及释放的影响。

Effects of droperidol on the biosynthesis and release of endogenous opioid peptides in guinea-pig ileum.

作者信息

Vargas M L, Martinez J A, Milanes M V

出版信息

Gen Pharmacol. 1987;18(3):283-6. doi: 10.1016/0306-3623(87)90012-7.

Abstract

Acute administration of droperidol 2 or 5 mg kg-1 induced an increase in the inhibitory response obtained by stimulation at 10 Hz of the myenteric plexus longitudinal muscle preparation of the guinea-pig ileum. The increase in the response induced by droperidol was markedly reduced by naloxone which suggests that it is mediated by endogenous opioid release. Cycloheximide treatment significantly reduced the increase of the inhibitory response induced by droperidol, indicating that the biosynthesis and the release of endogenous opioid are increased by droperidol.

摘要

急性给予氟哌利多2或5毫克/千克可使豚鼠回肠肌间神经丛-纵肌标本在10赫兹刺激下获得的抑制反应增强。纳洛酮可显著减弱氟哌利多诱导的反应增强，这表明其是由内源性阿片类物质释放介导的。放线菌酮处理可显著降低氟哌利多诱导的抑制反应增强，表明氟哌利多可增加内源性阿片类物质的生物合成和释放。