Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
Acta Obstet Gynecol Scand. 2011 Sep;90(9):961-5. doi: 10.1111/j.1600-0412.2011.01205.x. Epub 2011 Jul 18.
To compare cervical fluid nitric oxide release in women with and without Chlamydia trachomatis and high-risk human papillomavirus infection (hrHPV).
An open clinical study.
University Hospital of Helsinki.
Thirty-nine women with (n=21) and without C. trachomatis (n=18).
Chlamydia trachomatis and/or hrHPV were studied by using specific RNA- and DNA-based tests. Levels of cervical fluid nitric oxide metabolite (NOx) were assessed by the Griess reaction.
The difference in cervical fluid NOx between women with and without C. trachomatis and hrHPV.
Fourteen (67%) C. trachomatis-infected women and three (17%) noninfected women had concomitant hrHPV. The level of cervical fluid NOx in women with C. trachomatis (median 37.5 μmol/l, 95% confidence interval 26.1-50.9) was higher (p=0.02) than that in C. trachomatis-noninfected women (median 19.7 μmol/L, 95% confidence interval 5.6-30.0). The presence of hrHPV did not associate with any difference in NOx levels between C. trachomatis-infected or -noninfected women.
Chlamydia trachomatis was associated with increased release of nitric oxide metabolites in the uterine cervix. This stimulus was stronger than that of hrHPV, because no additional rise in NOx was seen in women with concomitant C. trachomatis and hrHPV infection.
比较沙眼衣原体和高危型人乳头瘤病毒（hrHPV）感染的女性与无感染的女性宫颈分泌物中一氧化氮的释放情况。
开放性临床研究。
赫尔辛基大学医院。
39 名女性，其中 21 名（n=21）有沙眼衣原体感染，18 名（n=18）无感染。
采用特定的 RNA 和 DNA 检测方法检测沙眼衣原体和/或高危型人乳头瘤病毒。通过格里塞反应评估宫颈分泌物中一氧化氮代谢物（NOx）的水平。
有和无沙眼衣原体和高危型人乳头瘤病毒感染的女性宫颈分泌物中 NOx 的差异。
14 名（67%）沙眼衣原体感染的女性和 3 名（17%）非感染的女性同时存在高危型人乳头瘤病毒感染。沙眼衣原体感染女性（中位数 37.5μmol/L，95%置信区间 26.1-50.9）的宫颈分泌物中 NOx 水平高于非感染女性（中位数 19.7μmol/L，95%置信区间 5.6-30.0）（p=0.02）。高危型人乳头瘤病毒的存在与沙眼衣原体感染或未感染女性的 NOx 水平无差异相关。
沙眼衣原体与子宫颈一氧化氮代谢物的释放增加有关。这种刺激比高危型人乳头瘤病毒更强，因为同时存在沙眼衣原体和高危型人乳头瘤病毒感染的女性中，NOx 没有进一步升高。
