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应激诱导的 HPA 轴激活可预测青少年静息状态下扣带回皮质下和突显网络之间的连接。

Stress-induced activation of the HPA axis predicts connectivity between subgenual cingulate and salience network during rest in adolescents.

机构信息

Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48202, USA.

出版信息

J Child Psychol Psychiatry. 2011 Oct;52(10):1026-34. doi: 10.1111/j.1469-7610.2011.02422.x. Epub 2011 Jun 3.

DOI:10.1111/j.1469-7610.2011.02422.x
PMID:21644985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3169772/
Abstract

BACKGROUND

Responses to stress vary greatly in young adolescents, and little is known about neural correlates of the stress response in youth. The purpose of this study was to examine whether variability in cortisol responsivity following a social stress test in young adolescents is associated with altered neural functional connectivity (FC) of the salience network (SN) measured during resting-state functional magnetic resonance imaging (rs-fMRI).

METHODS

Forty-nine typically developing young adolescents participated in a social stress test during which they contributed salivary cortisol samples. Following this, they underwent rs-fMRI scanning. We examined the association of FC of the SN [composed of anterior cingulate cortex and bilateral anterior insula regions] with cortisol responsivity.

RESULTS

Greater cortisol responsivity was significantly positively correlated with higher FC between subgenual anterior cingulate cortex (Cg25) and the SN, controlling for participant age. There were no regions of the brain that showed an inverse relation.

CONCLUSIONS

Brain systems that have been implicated in autonomic arousal and that influence subjective feeling states show altered FC associated with stress responsivity in early life.

摘要

背景

青少年对压力的反应差异很大，而对于年轻人对压力反应的神经相关因素知之甚少。本研究的目的是探讨青少年在社会压力测试后皮质醇反应的可变性是否与静息态功能磁共振成像(rs-fMRI)期间测量的显着网络(SN)的神经功能连接(FC)改变有关。

方法

49 名典型的发育中青少年参加了社会压力测试，在此期间他们提供了唾液皮质醇样本。在此之后，他们进行了 rs-fMRI 扫描。我们检查了 SN 的 FC[由前扣带皮层和双侧前岛叶区域组成]与皮质醇反应性之间的关联。

结果

皮质醇反应性越高，与控制参与者年龄的扣带回皮质下(subgenual anterior cingulate cortex, Cg25)和 SN 之间的 FC 呈显著正相关。没有发现大脑中存在与之相反的区域。

结论

与自主唤醒有关并影响主观感觉状态的大脑系统显示出与生命早期应激反应性相关的 FC 改变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1113/3169772/2ae76d6bddea/nihms295938f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1113/3169772/faac57ebce5c/nihms295938f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1113/3169772/7909edd551f9/nihms295938f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1113/3169772/2ae76d6bddea/nihms295938f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1113/3169772/faac57ebce5c/nihms295938f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1113/3169772/7909edd551f9/nihms295938f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1113/3169772/2ae76d6bddea/nihms295938f3.jpg

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2
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Annu Rev Clin Psychol. 2011;7:63-85. doi: 10.1146/annurev-clinpsy-032210-104507.
3
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4
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5
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6
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7
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8
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5
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6
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10
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