Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48202, USA.
Neuroimage. 2011 Mar 1;55(1):165-75. doi: 10.1016/j.neuroimage.2010.11.080. Epub 2010 Dec 4.
Resting-state MRI (rs-fMRI) is a powerful procedure for studying whole-brain neural connectivity. In this study we provide the first empirical evidence of the longitudinal reliability of rs-fMRI in children. We compared rest-retest measurements across spatial, temporal and frequency domains for each of six cognitive and sensorimotor intrinsic connectivity networks (ICNs) both within and between scan sessions. Using Kendall'sW, concordance of spatial maps ranged from .60 to .86 across networks, for various derived measures. The Pearson correlation coefficient for temporal coherence between networks across all Time 1-Time 2 (T1/T2) z-converted measures was .66 (p<.001). There were no differences between T1/T2 measurements in low-frequency power of the ICNs. For the visual network, within-session T1 correlated with the T2 low-frequency power, across participants. These measures from resting-state data in children were consistent across multiple domains (spatial, temporal, and frequency). Resting-state connectivity is therefore a reliable method for assessing large-scale brain networks in children.
静息态 MRI（rs-fMRI）是研究全脑神经连接的有力手段。在这项研究中，我们提供了 rs-fMRI 在儿童中纵向可靠性的第一个经验证据。我们比较了每个扫描会话内和之间的六个认知和感觉运动内在连接网络（ICN）的空间、时间和频率域的静息-重测测量值。使用 Kendall'sW，空间图谱的一致性在网络之间的各种衍生测量值中从.60 到.86 不等。所有时间 1-时间 2（T1/T2）z 转换测量值的网络之间的时间相干性的 Pearson 相关系数为.66（p<.001）。ICN 的低频功率在 T1/T2 测量值之间没有差异。对于视觉网络，参与者内的 T1 与 T2 的低频功率相关。这些来自儿童静息态数据的测量值在多个域（空间、时间和频率）上是一致的。因此，静息态连接是评估儿童大脑大网络的可靠方法。
